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If you choose to outsource, look for a Biostorage Service Provider with experience in cold chain logistics, not just storage. Providers should offer proven strategic expertise in planning, packaging, and transporting temperature sensitive materials.

Certification and expertise is a must. Check to see that a potential Biostorage Service Provider has:

Scaling Up

Make it a priority to choose Biostorage facilities systems designed to support changing needs. You may not currently foresee an expansion, but it is always a possibility, so you should know how you will accommodate a larger inventory.

2) Validation

Undocumented biospecimen storage practices can lead to a lack of confidence in the reliability of generated data. That’s why it is critically important that Biostorage Service Providers use robust, validated processes and controls. Standards to measure by include:

3) Mitigation

Mitigating risk with documented controls gives you the assurance that your organization’s biologics are secure in the event of an incident at your facility. Whether you are storing biospecimens onsite or off, they should be properly monitored and protected with:

Reporting

Your organization is responsible for upholding all regulatory mandates related to the procurement of human biospecimens, and should be prepared to address reporting requirements and audits. Be sure your chosen Biostorage Service Provider can give you the proper data access and frequency of reporting to successfully monitor:

ProMedDx delivers nearly 20 years of biologistics, biostorage, and biospecimen distribution expertise, providing complete control and transparency to biomaterial control and fulfillment. Our team of experts can assist you in your planning with an end-to-end solution and cGMP compliant workflows that protect biomaterials and research participants while providing the documented source to validate clinical trial data. To learn more, contact us or simply call 800.785.7808.

Key factors Clinical Ops and Researchers should consider when seeking a source for biospecimens

President Obama’s Precision Medicine Initiative (PMI) is gaining traction, and here’s the proof: National Institutes of Health recently awarded $142 million dollars to Mayo Clinic to help establish the world’s largest research-cohort biobank for the Precision Medicine Initiative Cohort Program. Clinical Operations Managers and Researchers in biopharm firms should feel encouraged by the promise of increased access to precision biospecimens.

But what about today? Biopharm can’t wait 5 years to begin to see the fruits of the PMI Cohort Program. Clinical Researchers need a trusted bioservice partner and source of precise biospecimens to fuel their research now.

Here are 4 factors Clinical Operations Managers and Researchers should consider when sourcing precision biospecimens:
800-808-8960 / info@trademarkcapital.com

We’re TRADEMARK. Like-minded individuals, united under a common vision: Adamant protection of investments during inevitable periods of risk.

{ Choose a path to discover the TRADEMARK difference }

Managed Accounts

Managed Accounts

Tactically balancing safety and return for two decades.

Retirement

Retirement

When it comes to retirement, failure is not an option.

We’re TRADEMARK. Like-minded individuals, united under a common vision: Adamant protection of investments during inevitable periods of risk.

At Trademark, we have a long history of offering tactical investment solutions – each designed to participate in up markets while staunchly protecting capital in down markets.

People are emotional. Investing shouldn’t be.

TRADEMARK seeks protection of your assets during rough times in the market, while keeping you on track towards achieving your goals .

Successful investors do not avoid risk. They manage it.

TRADEMARK: Steady guidance from Don Beasley, an innovator in tactical risk management since 1991.

Managed Accounts

TRADEMARK provides a suite of separate managed account strategies designed to help individuals achieve their investment goals with as little emotional stress as possible. Each of our strategies have varying primary objectives but all have an equal emphasis on the most important aspect of successful investing – avoiding large losses.

Tactical Risk Strategy Factsheet

Tactical Risk Strategy Pitchbook

Trademark Investment Strategies

Tactical Risk Strategy Overview
Our TRS process

Our flagship, tactical unconstrained, portfolio seeks to participate in equity markets during lower-risk, constructive market environments and staunchly protect our investors’ capital in down markets. We utilize exchange traded funds (ETFs) to create and tactically adjust a diversified and balanced portfolio according to current market conditions.

We use a proprietary quantitative model to measure current market risk conditions. This helps us identify if the market is in a constructive environment or a higher-risk environment. Based on our risk model’s assessment we can tactically adjust our portfolio between a diversified allocation with a heavy equity bias all the way down to a fully cash or cash equivalent allocation during the highest risk environments.

Assess Market Risk, Build Portfolio of ETFs according to risk, Manage Portfolio

Retirement

We have a long tradition of helping retirement plan sponsors and plan participants invest for their retirement goals and objectives. Our innovative tactical risk managed solutions are designed to help our clients by mitigating their exposure to destructive market losses.

Tactical Risk Series Brochure

Tactical Risk Series Fact Sheet

Tactical Risk Series Pitchbook

Cash Balance Pitchbook

Retirement Plan Strategies

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What is a CIT?
Trademark Cash Balance Strategy (CBIS)
Our CBIS Process

Plan sponsors today are faced with the challenge of choosing the right target-date solution for their participants. While it is important to take into account a TDF’s investment objective and glidepath methodology, it is also important to understand the fund’s ability to protect participants’ retirement savings during times of market volatility.

What makes Trademarks’ retirement series unique is our Tactical Risk Overlay – an allocation within each fund designed to provide significant downside protection. While dynamic, the percentage allocated to the Tactical Risk Overlay increases as an investor approaches their retirement age and throughout their golden years.

Collective trust funds, also known as collective investment trusts (CITs), are pooled investment vehicles maintained by a bank or trust company. Like mutual funds, CITs combine the assets of various organizations to create a large, well-diversified portfolio, and their investors own shares of the CIT. Unlike mutual funds, CITs are available exclusively to qualified retirement plans, including 401(k) and certain government, pension, and profit sharing plans.

The defined contribution market has shown increasing interest in CITs because of their ability to satisfy plan sponsor demand for institutional-quality investment management, while potentially offering lower participant costs.

Lower Cost:

CITs may have a lower fee structure than mutual funds because mutual funds typically charge shareholders for regulatory and administrative expenses as well as marketing and distribution costs.

Fiduciary Standards:

CIT Trustees are held to ERISA fiduciary standards, meaning that the bank must act solely in the best interest of the plan participants and beneficiaries.

Fee Structure Flexibility:

CITs are not limited by the retail mutual funds share class structure, which allows for greater pricing flexibility for both the advisor and plan sponsor.

CITs are regulated by the Office of the Comptroller of the Currency (OCC) or state banking laws and are subject to the Employee Retirement Income Security Act of 1974 (ERISA). CITs are not available to retail investors, and therefore are exempt from some of the regulatory requirements that apply to mutual funds, including registration with the SEC under the Investment Company Act of 1940.

CITs are designed exclusively for tax-exempt, qualified retirement plans.

Trademark’s innovative Cash Balance Investment Solution (CBIS) has been developed to address the very specific requirements of a cash balance plan – to target the interest crediting rate of the 30 year Treasury bond yield.

Few products are available in the industry for these specific needs and of those the primary strategy has been to employ a heavy or exclusive allocation to fixed income investments. In the current low yield environment for fixed income this makes achieving the investment objective of cash balance plans difficult while increasing potential risk of loss should interest rates rise.

At Trademark, we believe a balanced approach INCLUDING an allocation to equity is important to achieve the return requirements for cash balance plans – but we also understand the consequences of losses. That is why we are well positioned to provide this need. Our philosophy is to protect from large losses by having the flexibility to tactically reduce (or remove) exposure to high risk market environments – and our portfolio managers have been doing it for clients since 1991.

The CBIS portfolio was developed to address the specific needs of cash balance pension plans. Most cash balance pension plans need a steady return equal to the 30-year Treasury bond yield, or slightly in excess of that benchmark, with low volatility. Our portfolio is constructed to target this benchmark and benefits from Trademark’s overriding emphasis of capital preservation during periods of market unrest. We tactically manage our exposure to both the equity and fixed income positions to avoid unnecessary risks during down markets.

The CBIS strategy is innovative in that it also protects returns when the benchmark rate is achieved during the year. This is monitored on a calendar year basis. No matter when the benchmark return is achieved during the year, once it has been reached the strategic allocation is moved to more fixed income to protect the gains.

About

Trademark Capital is a boutique investment management firm that provides tactical ETF portfolio solutions. For over two decades, Trademark’s principals have managed tactical portfolios aimed to maximize wealth by minimizing large losses.

We do not manage strategies to outperform an index or benchmark.We believe our tactical risk strategies reduce the chances of making emotional investment decisions and, in return, may increase investors’ likelihood of meeting their long-term goals.

Trademark offers tactical investment solutions via managed accounts as well as Collective Investment Funds for qualified retirement plans.

Don Beasley

Principal Managing Director

Don Beasley is a Principal Managing Director at Trademark Capital. Don began his professional money management career in 1988 and has been a nationally featured speaker on topics including technical market analysis and quantitative criteria for mutual fund selection and management. Throughout Don’s career, he has been a pioneer in the industry and instrumental in creating and improving a technology-driven, actively managed investment model that continues to be an integral part of Trademark’s investment management philosophy today. Don’s unwavering belief that missing down markets is the most important part of capital preservation has allowed him to help improve the investment experience for clients. He continues to balance the quantitative model with a distinct need to protect every dollar he manages. Prior to working at Trademark, Don co-founded Personal Mutual Fund Management (PMFM), Inc. in 1991 (presently Stadion Money Management). Don received two Bachelor of Science degrees in Math and Physical Education and a Masters in Administration from Northwestern State University. He also holds the Series 65 license (Uniform Investment Advisor). Don lives in Athens, Georgia with his wife. A former NCAA basketball coach, Don is an avid outdoorsman who enjoys deer hunting and spending time with his nieces and nephews.

“It does not matter how frequently something succeeds – if failure is too costly to bear.”

“If you don’t stand for something… you’ll fall for anything.”

“Avoiding large losses is more important to one’s investment return than just asset allocation”

Principal Managing Director

Quantitative PCR were performed according to [ BUTY PUMA TSUGI SHINSEI 364121 01 6 nJNuihG
, 27 ]. Real-time PCR primer sequences were as follow: b (F: CCCTCATCCTGTTCGATTTGGT; R: TGAAGATGCACGGCCTCATTATG), b (NKCC2β) (F: TGTGTGATGATGTCCGCTG; R: CAAGACGTGCTGAGTGTCATA), a (NKCC1α) (F: AGCGATACAGAAAGACGAC; R: CTTCTTCTGGAACTGCTGAC), (F: ACGTTTGTGTGGAGAAGGAG; R: TCGCAGTACGTCATGTCAATC), (F: CTTTGAGCTTCGCCTGTCT; R: CAGCTCTGTCCCAGCAAATA), and (F: CTGAAGCCTGGTATGGTGGT; R: ACGACGGATTTCCTTGACAG).

The total RNAs of eel gill (FW 1h [=3], SW 1h [=3], FW 3h [=3], SW 3h [=3]), anterior (FW 1h [=3], SW 1h [=2], FW 3h [=3], SW 3h [=2]) and posterior intestines (FW 1h [=3], SW 1h [=5], FW 3h [=3], SW 3h [=5]) were extracted using Isogen, reverse transcribed to cDNA libraries according to [ 26 ]. For eel RNA-seq, the sequenced reads were mapped to the Japanese eel genome [ Grunland CE0585 LINO Ciabatta Uomo P Testa Di Moro FRjlK
] using TopHat (version 2.0.9) [ NVXIE Womens Ladies Over Knee Thigh Boots Delight Long Boot Sexy High Heel Patent leather Waterproof Black Fall Winter Stage Nightclub EUR38UK55 pq06gsQ7mH
]. The mapped reads were pooled for each condition, and genome-guided transcriptome assembly was performed to reconstruct the eel transcripts using Cuffilink version 2.1.1. The assembled transcripts were merged using Cuffmerge, and the merged transcripts were used for quantifying gene expression levels.

For each eel transcript, open reading frames (ORFs) were predicted using EMBOSS getorf (version 6.6.0) [ Nike Womens Zoom Fit Training Shoe Blue Lagoon/Dark Grey/Cp/White InNHJ
] with the parameter “-minsize 300”. Then, for each gene, the longest ORF among ORFs predicted from all transcripts belonging to the gene was selected, and the translated amino acid sequence of the ORF was used for the following blast search. The reciprocal blast search was performed using amino acid sequences of medaka and eel using BLASTP in NCBI-BLAST+ (version 2.2.29+) [ 31 ] with the parameter “-evalue 1e-5”. Longest amino acid sequence for each medaka gene in Ensembl annotation (release 74) was used. Then, the reciprocal BLAST best hits (RBBH) in terms of E-value were defined as RBBHs between medaka and eel. Gene annotation of eel was guided using the medaka genome as reference database with RBBH. Only genes with at least 10 reads in at least 2 samples were used in the following analysis and low-count genes were removed. The relative gene expression was normalized using the iDEGES method implemented in the TCC package (version 1.2.0) [ 32 ]. Transcriptome data of intestine and gill in eel was deposited in DDBJ database with accession number DRA004257 and DRA004258 respectively.

As the histology data suggested major involvement of mucus cells and desquamation of epithelia, we analyzed the known epithelial growth factors and the gene family members in goblet cells [ Divine Follie 63270G Meat Glitter dcollet Closed Toe Heels Woman Glitter Beige oQDs9XdIK
] to deepen our understanding of the dynamic changes of the epithelia globally. We used and as reference markers for the mucus cells. Genes with upregulation, downregulation, and unchanged expression were all included for the protein interaction analysis but gene expression less than 50 reads/million on average were excluded from further analyses.

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